By Albert Neuberger, L. L. M. Van Deenen, Giorgio Semenza

ISBN-10: 0444805079

ISBN-13: 9780444805072

ISBN-10: 0444807020

ISBN-13: 9780444807021

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However, infection of the host with irradiated phage did result after an initial lag of 3 min in the formation of an amount of dCMP hydroxymethylase over the first 15 min comparable to that found for unirradiated phage. These experiments thus divided the infection into pre- and postreplicative periods. From this temporal sequence the components synthesized during the prereplicative period have been designated as 'early' functions and during the post-replicative period as 'late' functions. As was found later, these periods can be further subdivided based on effects of several inhibitors of protein synthesis [184,185] and by the expression of bacterial phage products from radioactive precursors as measured by polyacrylamide gel electrophoresis and autoradiography [186,187].

FGAR amidotransferase was purified from Salmonella typhimurium by Thayer French and Igor Dawid [123] and from chicken liver by Kiyoshi Mizobuchi [124]. With either type of preparation there is approximately a mole-for-mole reaction of azaserine with enzyme. The reactive residue of the enzymes is a cysteine. The amino acid sequence around this residue has been determined on the bacterial enzyme by French and Dawid [125,126] and on the liver enzyme by Shiro Ohnoki and Bor-Shye Hong [127,128]. M. BUCHANAN aminopropionic acid and bears perhaps a closer structural relationship to glutamine.

If either antibiotic is incubated with enzyme in the absence of glutamine, activity is immediately lost and is not regained by addition of glutamine. This type of inhibition differed, for example, from the inhibition by malonate of succinic dehydrogenase, which is a simple function of the ratio of the concentrations of the substrate, succinate, and the inhibitor. The characteristics of the inhibition by azaserine or DON, however, indicated that their structural similarity to glutamine permitted their interaction at the enzyme site for the natural substrate, but once in position an irreversible reaction with the enzyme occurred.

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A History of Biochemistry: Selected Topics in the History of Biochemistry Personal Recollections. II. by Albert Neuberger, L. L. M. Van Deenen, Giorgio Semenza


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