By Bethel Solomons (Auth.)

ISBN-10: 1483167895

ISBN-13: 9781483167893

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Example text

Sometimes cranial bone abnormalities occur. teeth m a y be present. Defective CONGENITAL TELANGIECTATIC ERYTHEMA RESEMBLING LUPUS ERYTHEMATOSUS IN DWARFS T h i s r a r e d i s o r d e r is c h a r a c t e r i z e d b y l u p u s e r y t h e m a t o s u s - l i k e lesions o n t h e b u t t e r f l y a r e a of t h e face, w i t h a b u l l o u s e r u p t i o n o n t h e l o w e r lip. T h e lesions a r e m a d e w o r s e b y s u n l i g h t . I c h t h y o t i c lesions a r e p r e s e n t o n t h e flanks a n d axillae.

M a y a p p e a r a t a b o u t 2 y e a r s of a g e , o r l a t e r , u p t o a d u l t life. I N H E R I T A N C E . — D i s e a s e m a y a r i s e de novo b y m u t a t i o n o r a s simple d o m i n a n t . S E X . — M a l e s c o m m o n l y affected. S E A S O N . — W o r s e in s u m m e r . M E T A B O L I S M . , f a i l u r e of cells t o u t i l i z e t h e v i t a m i n p r o p e r l y . P a t h o l o g y . — H y p e r k e r a t o s i s , e s p e c i a l l y of follicles, a n d a c a n t h o s i s a r e p r e s e n t .

O t h e r m a l f o r m a t i o n s m a y b e p r e s e n t , s u c h a s h a r e - l i p , cleft p a l a t e , o r m u l t i p l e naevi of c o n j u n c t i v a e o r face. T r e a t m e n t . — N o n e effective. P r o g n o s i s . — 2 0 per cent mortality, due to meningitis. CONGENITAL DERMAL SINUSES These sinuses are d e r m a l t u b e s e x t e n d i n g inwards, a n d often connecti n g t h e c e n t r a l n e r v o u s s y s t e m o r i t s c o v e r i n g s w i t h t h e s u r f a c e of t h e b o d y .

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A Synopsis of Skin Diseases by Bethel Solomons (Auth.)

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